Laboratory for Biological Systems Analysis
Home     People     Research     Publications     News     Software

Modeling of Early Events in Atherosclerosis

This project aims to improve our understanding or the early events leading to plaque formation and inflammation in endothelial tissues of the vascular system in humans. Special emphasis is placed on the roles of bone morphogenic protein 4 (BMP4), various NADPH oxidases, and a number of reactive oxygen species. The modeling efforts address metabolic, as well as gene regulatory and signaling events.


[1] Yin, W., H. Jo, and E.O. Voit: Systems analysis of the role of bone morphogenic protein 4 in endothelial inflammation. Ann. Biomed. Eng. 38(2): 291-307, 2010.

[2] Yin, W., and E.O. Voit: Function and design of the Nox1 system in vascular smooth muscle cells (submitted).

Click image to view: