Laboratory for Biological Systems Analysis
Home     People     Research     Publications     News     Software

Pathway Modeling for Sustainable Biofuel Production

This project addresses the industrial production of biofuels, such as ethanol. In particular, it focuses on the biosynthesis of lignin, a component of higher plants that makes plant biomass difficult to digest enzymatically. The project uses a variety of methods, including Flux Balance Analysis (FBA), Biochemical Systems Theory (BST) and a variety of optimization techniques. Among other technical processes, the project aims to convert FBA models into fully kinetic BST models.



References:

[1] Torres, N.V., and E.O. Voit: Pathway Analysis and Optimization in Metabolic Engineering. Cambridge University Press, Cambridge, U.K., 2002.

[2] Lee, Y. and E.O. Voit: Mathematical modeling of monolignol biosynthesis in Populus. Math. Biosc., 228(1): 78-89, 2010.

[3] Lee, Y., F. Chen, L. Gallego-Giraldo, R.A. Dixon, and E.O. Voit: Integrative analysis of transgenic alfalfa (Medicago sativa L.) suggests new metabolic control mechanisms for monolignol biosynthesis, PLoS Comp. Biol. 7(5): e1002047. doi:10.1371, 2011.

[4] Lee, Y., L. Escamilla-Treviño, R.A. Dixon, and E.O. Voit: Functional Analysis of Metabolic Channeling and Regulation in Lignin Biosynthesis: A Computational Approach (submitted).


Click image to view:
Pathway Analysis and Optimization in Metabolic Engineering Pathway Analysis and Optimization in Metabolic Engineering Pathway Analysis and Optimization in Metabolic Engineering
from [2] from [1] from [1]