Pathway Modeling for Sustainable Biofuel Production
This project addresses the industrial production of biofuels, such as ethanol. In particular, it focuses on the biosynthesis of lignin, a component of higher plants that makes plant biomass difficult to digest enzymatically. The project uses a variety of methods, including Flux Balance Analysis (FBA), Biochemical Systems Theory (BST) and a variety of optimization techniques. Among other technical processes, the project aims to convert FBA models into fully kinetic BST models.
 Torres, N.V., and E.O. Voit: Pathway Analysis and Optimization in Metabolic Engineering. Cambridge University Press, Cambridge, U.K., 2002.
 Lee, Y. and E.O. Voit: Mathematical modeling of monolignol biosynthesis in Populus. Math. Biosc., 228(1): 78-89, 2010.
 Lee, Y., F. Chen, L. Gallego-Giraldo, R.A. Dixon, and E.O. Voit: Integrative analysis of transgenic alfalfa (Medicago sativa L.) suggests new metabolic control mechanisms for monolignol biosynthesis, PLoS Comp. Biol. 7(5): e1002047. doi:10.1371, 2011.
 Lee, Y., L. Escamilla-Treviño, R.A. Dixon, and E.O. Voit: Functional Analysis of Metabolic Channeling and Regulation in Lignin Biosynthesis: A Computational Approach (submitted).
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