News
The international conference "Frontiers in Systems and Synthetic Biology '13" is organized by the lab, with the help of the Integrative Biosystems Institute.
Click here for more information.
New Textbook
Voit, E.O.: A First Course in Systems Biology. Garland Science, New York, NY, 2012, xiv+445pp.
This new textbook was published by Garland in 2012. It is a true introduction to the field of computational systems biology and contains over 300 figures and over 300 exercises.
Click here for more information on this new text.
New Comprehensive Review
Voit, E.O.: Biochemical Systems Theory: A review. Int. Scholarly Res. Network (ISRN – Biomathematics), Article 897658, pp. 1-53, 2013.
2011-2013 Papers
Chen, P.-W., L.L. Fonseca, Y.A. Hannun, and E.O. Voit: Coordination of rapid sphingolipid responses to heat stress in yeast (in revision).
Yin, W., and E.O. Voit: Function and design of the Nox1 system in vascular smooth muscle cells. BMC Syst. Biol. 7:20, 2013.
Voit, E.O.: Characterizability of metabolic pathway systems from time series data. Math. Biosc. (in press).
Voit, E.O.: Mesoscopic modeling as a starting point for computational analyses of cystic fibrosis as a systemic disease. Biochim. Biophys. Acta – Proteins and Proteomics (invited and submitted).
Qi, Z., D. Fieni, F. Tretter, and E.O. Voit: The neurochemical mobile with nonlinear interaction matrix: An exploratory computational model. Pharmacopsychiatry (in press)
Qi, Z., G.W. Miller, and E.O. Voit: Mathematical Models of Dopamine Metabolism in Parkinson’s Disease. in Volume P. Wellstead and M. Cloutier (Eds.): The Systems Biology of Parkinson’s Disease. Springer Verlag, New York, 2012.
S. Kikuchi and E.O. Voit: Regulatory Crosstalk Analysis of Biochemical Networks in the Hippocampus and Nucleus Accumbens. In C. Béla and A. Prokop (Eds.) Systems Biology. Springer Verlag, New York, 2013 (in press).
Lee, Y., L. Escamilla-Treviño, R.A. Dixon, and E.O. Voit: Functional Analysis of Metabolic Channeling and Regulation in Lignin Biosynthesis: A Computational Approach. PLoS Comp. Biol. 8, 11, 2012.
Voit, E.O., W.C. Newstetter, and M.L. Kemp: A feel for systems. Mol. Syst. Biol. 8, 609, 2012
Chou, I-C., and E.O. Voit: Estimation of dynamic flux profiles from metabolic time series data, BMC Syst. Biol. 6: 84, 2012.
Fonseca, L.L., P.W. Chen, and E.O. Voit: Canonical modeling of the multi-scale regulation of the heat stress response in yeast. Metabolites 2(1), 221-241, 2012.
Voit, E.O., Z. Qi, and S. Kikuchi: Mesoscopic models of biomedical systems as intermediates between disease simulators and tools for discovering design principles: Dopamine-related diseases as case study. Pharmacopsychiatry 45 (S1), S22-S30, 2012.
Qi, Z., G.W. Miller, and E.O. Voit. Mathematical Models of Dopamine Metabolism in Parkinson's Disease. in Volume P. Wellstead and M. Cloutier (Eds.): The Systems Biology of Parkinson's Disease. Springer Verlag, New York, 2012.
Finn, N.A. G. Dwivedi, E.O. Voit, and M.L. Kemp: Modeling Non-Equilibrium Redox Enzymatic Systems. In: W. Dubitzky, O. Wolkenhauer, K. Cho, and H. Yokota (Eds.) Encyclopedia of Systems Biology. (invited) Springer Science + Business Media, LLC 2012.
Dwivedi, G., N.A. Finn, E.O. Voit, and M.L. Kemp: Model Implementation of Experimental Perturbations. In: W. Dubitzky, O. Wolkenhauer, K. Cho, and H. Yokota (Eds.) Encyclopedia of Systems Biology. (invited) Springer Science + Business Media, LLC 2012.
Lee, Y., I-C. Chou, M.L. Kemp, and E.O. Voit: From Steady State to Dynamics: Metabolic Flux Analysis Taken One Step Further. In: W. Dubitzky, O. Wolkenhauer, K. Cho, and H. Yokota (Eds.) Encyclopedia of Systems Biology. (invited) Springer Science + Business Media, LLC 2012.
Chou, I-C., Z. Qi, M.L. Kemp, and E.O. Voit: Metabolic System Identification from Different Experimental Data. In: W. Dubitzky, O. Wolkenhauer, K. Cho, and H. Yokota (Eds.) Encyclopedia of Systems Biology. (invited) Springer Science + Business Media, LLC 2012.
Fonseca, L., W. Yin, M.L. Kemp, and E.O. Voit: Modeling Metabolic Systems with Power-law Functions. In: W. Dubitzky, O. Wolkenhauer, K. Cho, and H. Yokota (Eds.) Encyclopedia of Systems Biology. (invited) Springer Science + Business Media, LLC 2012.
Qi, Z., G.W. Miller, and E.O. Voit. Mathematical Models in Schizophrenia. Chapter 14 in Volume I of: M.S. Ritsner (Ed.):Textbook of Schizophrenia Spectrum Disorders. Springer Verlag, New York, 2011.
Voit, E.O.: What if the fit is unfit? Criteria for biological systems estimation beyond residual errors. In: M. Dehmer, F. Emmert-Streib and A. Salvador (Eds.): Applied Statistics for Biological Networks. J. Wiley and Sons, New York, pp. 183-200, 2011.
Wu, J., Z. Qi, and E.O. Voit: Investigation of delays and noise in dopamine signaling with hybrid functional Petri nets. In: E. Wingender (Ed): Biological Petri Nets. IOS Press Publications, Amsterdam, 2011.
Alvarez-Vasquez, F., H. Riezman, E. O. Voit, and Y. A. Hannun. Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. PLoS One 6(12): e28344, 2011.
Wu, J., B. Vidakovic, and E. O. Voit: Constructing stochastic models from deterministic process equations by propensity adjustment. BMC Syst. Biol. 5:187, 2011.
Qi, Z., S. Kikuchi, F. Tretter, and E.O. Voit: Effects of dopamine and glutamate on synaptic plasticity: A computational modeling approach for drug abuse as comorbidity in mood disorders. Pharmacopsychiatry 44(Suppl. 1): S62-S75, 2011.
Lee, Y., F. Chen, L. Gallego-Giraldo, R.A. Dixon, and E.O. Voit: Integrative analysis of transgenic alfalfa (Medicago sativa L.) suggests new metabolic control mechanisms for monolignol biosynthesis, PLoS Comp. Biol. 7(5): e1002047. doi:10.1371, 2011.
Lee, Y., P.-W. Chen, and E.O. Voit: Analysis of operating principles with S-system models. Math. Biosc. 231, 49-60, 2011.
Ndukum, J. L.L. Fonseca, H. Santos, E.O. Voit, and S. Datta: Statistical inference methods for sparse biological time series data. BMC Syst. Biol. 5:57, 2011.
Fonseca, L.L., C. Sánchez, H. Santos, and E.O. Voit: Complex coordination of multi-scale cellular responses to environmental stress. Mol. BioSyst. 7 (3), 731 - 741; DOI:10.1039/C0MB00102C, 2011.
Voit, E.O., and M.L. Kemp: So, you want to be a Systems Biologist? Determinants for Creating Graduate Curricula in Systems Biology. IET Systems Biol. 5(1): 70-79, 2011.
Perthame, B. and E.O.Voit: The Thirteenth Bellman Prize announcement. Math. Biosc. 234(2), 154-155, 2011.